This article has surfaced in light of Tomas Lindahl, Paul Modrich and Aziz Sancar's joint awarding of the nobel prize for chemistry. The reparation of DNA is due to a nitrogenous base found in RNA called uracil being, in the place of cytosine, is "loaded" into the double helix. This loading of uracil happens 200 times a day in every cell of the body. On whole. millions of repairs are necessary daily. This is called base excision repair. DNA has to be repaired in such as a way when it gets miscopied when dividing into two daughter cells. This is when the DNA gets copied to form one of the strands for the daughter cell.
"Together our three Nobel laureates have explained the basic mechanisms that help to guard the integrity of our genomes" Claes Gustaafsson - Chairman of the Nobel Chemistry Committee.
What I found so interesting about this topic is that the DNA has to know that it is incorrectly miscopied to be able to load uracil into the DNA to "fix" it. Is there some sort of check like cyclins to see if it is miscopied and what if that fails? Is the DNA localised or can it affect multiple cells?